CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy.

CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy.

Maladaptive cardiac hypertrophy predisposes one to arrhythmia and sudden death. Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) promote anti-inflammatory and antiapoptotic mechanisms, and are involved in the regulation of cardiac Ca(2+)-, K(+)- and Na(+)-channels. To test the hypothes...

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Main Authors: Christina Westphal, Bastian Spallek, Anne Konkel, Lajos Marko, Fatimunnisa Qadri, Laura M DeGraff, Carola Schubert, J Alyce Bradbury, Vera Regitz-Zagrosek, John R Falck, Darryl C Zeldin, Dominik N Müller, Wolf-Hagen Schunck, Robert Fischer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0073490
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https://doi.org/10.1371/journal.pone.0073490

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