Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies.

Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies.

Common intronic variants in the Human fat mass and obesity-associated gene (FTO) are found to be associated with an increased risk of obesity. Overexpression of FTO correlates with increased food intake and obesity, whilst loss-of-function results in lethality and severe developmental defects. Despi...

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Main Authors: Daniel P S Osborn, Rosa Maria Roccasecca, Fiona McMurray, Victor Hernandez-Hernandez, Sriparna Mukherjee, Inês Barroso, Derek Stemple, Roger Cox, Philip L Beales, Sonia Christou-Savina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0087662
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https://doi.org/10.1371/journal.pone.0087662

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