TET1 displays catalytic and non-catalytic functions in the adult mouse cortex

TET1 displays catalytic and non-catalytic functions in the adult mouse cortex

TET1/2/3 dioxygenases iteratively demethylate 5-methylcytosine, beginning with the formation of 5-hydroxymethylcytosine (5hmC). The post-mitotic brain maintains higher levels of 5hmC than most peripheral tissues, and TET1 ablation studies have underscored the critical role of TET1 in brain physiolog...

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Bibliographic Details
Main Authors: Yee Hoon Foong, Blake Caldwell, Joanne L. Thorvaldsen, Christopher Krapp, Clementina A. Mesaros, Wanding Zhou, Rahul M. Kohli, Marisa S. Bartolomei
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Epigenetics
Subjects:
TET1
DNA demethylation
DNA hydroxymethylcytosine
dioxygenases
adult mouse cortex
Infinium BeadChip array
Online Access:https://www.tandfonline.com/doi/10.1080/15592294.2024.2374979
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https://www.tandfonline.com/doi/10.1080/15592294.2024.2374979

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