Kavain Alleviates Choroidal Neovascularization Via Decreasing the Activity of the HIF-1α/VEGF-A/VEGFR2 Signaling Pathway and Inhibiting Inflammation

Kavain Alleviates Choroidal Neovascularization Via Decreasing the Activity of the HIF-1α/VEGF-A/VEGFR2 Signaling Pathway and Inhibiting Inflammation

Purpose: Neovascular age-related macular degeneration (nAMD) is a prevalent cause of blindness in the elderly. Standard treatment includes anti-vascular endothelial growth factor (anti-VEGF) drugs, such as aflibercept. However, anti-VEGF drugs may have limited efficacy and cause drug resistance. Thi...

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Main Authors: Xi Chen, Xun Qin, Wen Bai, Junsong Ren, Yang Yu, Huiling Nie, Xiumiao Li, Zhangyu Liu, Jiayu Huang, Juxue Li, Jin Yao, Qin Jiang
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2024-07-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
neovascular age-related macular degeneration
kavain
anti-inflammation
anti-angiogenesis
choroidal neovascularization
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-14-469.pdf
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