Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma

Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma

IntroductionSkin cutaneous melanoma (SKCM) is a highly aggressive form of cancer with poor prognosis, characterized by significant molecular and immune heterogeneity. The activation of KRAS signaling pathways is implicated in melanoma progression, yet its role in shaping the tumor microenvironment,...

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Main Authors: Beichen Cai, Qian Lin, Ruonan Ke, Jiaqi Yu, Lu Chen, Xuejun Ni, Hekun Liu, Xiuying Shan, Biao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
melanoma
KRAS signaling
macrophage infiltration
prognostic biomarker
immune microenvironment
single-cell RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1566432/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1566432/full

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