A plasma biomarker panel for detecting early amyloid-β accumulation and its changes in middle-aged cognitively unimpaired individuals at risk for Alzheimer’s diseaseResearch in context

A plasma biomarker panel for detecting early amyloid-β accumulation and its changes in middle-aged cognitively unimpaired individuals at risk for Alzheimer’s diseaseResearch in context

Summary: Background: Plasma biomarkers of Alzheimer’s disease (AD) change during preclinical stages, indicating potential for detecting amyloid-β (Aβ) pathology in cognitively unimpaired (CU) individuals. Given the need for accurate, scalable biomarkers, we evaluated a fully automated plasma panel...

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Main Authors: Armand González-Escalante, Marta Milà-Alomà, Wagner S. Brum, Nicholas J. Ashton, Paula Ortiz-Romero, Mahnaz Shekari, Marta del Campo, Federica Anastasi, Clara Quijano-Rubio, Gwendlyn Kollmorgen, Carolina Minguillón, Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, Juan Domingo Gispert, Henrik Zetterberg, Natalia Vilor-Tejedor, Kaj Blennow, Marc Suárez-Calvet
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:EBioMedicine
Subjects:
Alzheimer
Biomarkers
Dementia
Diagnosis
Plasma
Modelling
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425001859
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http://www.sciencedirect.com/science/article/pii/S2352396425001859

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