“Relative symmetry with electronegativity of different key-groups” strategy for MRGPRX2 antagonist design and its effect on antigen-induced pulmonary inflammation

“Relative symmetry with electronegativity of different key-groups” strategy for MRGPRX2 antagonist design and its effect on antigen-induced pulmonary inflammation

MRGPRX2 antagonists possess the potential for the treatment of allergic rhinitis, atopic dermatitis, and chronic urticaria. Previously, we identified a class of diaryl urea (DPU) MRGPRX2 antagonists with sub-micromolar IC50 values in vitro. However, the structure–activity relationship remains unclea...

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Bibliographic Details
Main Authors: Jiayu Lu, Zhaomin Xia, Yongjing Zhang, He Wang, Wen Yang, Siqi Wang, Nan Wang, Yun Liu, Huaizhen He, Cheng Wang, Langchong He
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
MRGPRX2
Antagonist
Diaryl urea
Relative symmetry with electronegativity
Antiallergic activity
Antigen-induced pulmonary inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524004568
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