The effect of travoprost on primary human limbal epithelial cells and the siRNA-based aniridia limbal epithelial cell model, in vitro.

The effect of travoprost on primary human limbal epithelial cells and the siRNA-based aniridia limbal epithelial cell model, in vitro.

<h4>Purpose</h4>Haploinsufficiency of the PAX6 gene is the primary pathogenic mechanism underlying classical congenital aniridia. Notably, at least 50% of patients with this condition develop glaucoma. Prostaglandin analogues, such as travoprost, are widely used to lower intraocular pres...

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Main Authors: Shuailin Li, Tanja Stachon, Shanhe Liu, Zhen Li, Shao-Lun Hsu, Swarnali Kundu, Fabian N Fries, Berthold Seitz, Maryam Amini, Shweta Suiwal, Nóra Szentmáry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0330492
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https://doi.org/10.1371/journal.pone.0330492

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