Lumpy skin disease virus ORF142 protein inhibits type I interferon production by disrupting interactions of TBK1 and IRF3

Lumpy skin disease virus ORF142 protein inhibits type I interferon production by disrupting interactions of TBK1 and IRF3

Abstract Background Lumpy skin disease virus (LSDV) causes lumpy skin disease, which is one of the most devastating ruminant diseases. The pathogenesis of the disease remains largely unknown; however, the disease seriously threatens the global cattle-farming industry. In our previous study, we found...

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Bibliographic Details
Main Authors: Zihan Chen, Jingyu Wang, Baochun Lu, Heyu Li, Chuanli Liu, Huijuan Zeng, Jinping Chen, Shizhe Liu, Qifeng Jiang, Kun Jia
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Veterinary Research
Subjects:
LSDV
ORF142
IRF3
TBK1
Immune evasion
Online Access:https://doi.org/10.1186/s12917-025-04714-y
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https://doi.org/10.1186/s12917-025-04714-y

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