Epigenetic age acceleration mediates the association between low-grade systemic inflammation and cardiovascular diseases: insight from the NHANES 1999–2002

Epigenetic age acceleration mediates the association between low-grade systemic inflammation and cardiovascular diseases: insight from the NHANES 1999–2002

Abstract Background Currently, with the global aging of the population, inflammation, recognized as a hallmark in age-related diseases, has been studied and linked to cardiovascular diseases (CVD). However, limited evidence on whether inflammation modifies epigenetic aging and affects CVD risk. Meth...

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Bibliographic Details
Main Authors: Xiaolang Chen, Jin Zhong, Yingnan Lv, Lancheng Wei, Huijiao Zhou, Yongmei Yang, Jinfan Chi, Zhen Lee, Huabei Wu, Haiying Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Clinical Epigenetics
Subjects:
Cardiovascular disease
Epigenetic age acceleration
Low-grade systemic inflammation
Mediation
NHANES
Online Access:https://doi.org/10.1186/s13148-025-01895-z
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https://doi.org/10.1186/s13148-025-01895-z

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