Discovery of Non-Peptide GLP-1 Positive Allosteric Modulators from Natural Products: Virtual Screening, Molecular Dynamics, ADMET Profiling, Repurposing, and Chemical Scaffolds Identification

Discovery of Non-Peptide GLP-1 Positive Allosteric Modulators from Natural Products: Virtual Screening, Molecular Dynamics, ADMET Profiling, Repurposing, and Chemical Scaffolds Identification

<b>Background/Objectives:</b> Glucagon-like peptide-1 (GLP-1) receptor is currently one of the most explored targets exploited for the management of diabetes and obesity, with many aspects of its mechanisms behind cardiovascular protection yet to be fully elucidated. Research dedicated t...

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Bibliographic Details
Main Authors: Mohamed S. Gomaa, Mansour S. Alturki, Nada Tawfeeq, Dania A. Hussein, Faheem H. Pottoo, Abdulaziz H. Al Khzem, Mohammad Sarafroz, Samar Abubshait
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceutics
Subjects:
GLP-1
natural products
virtual screening
molecular dynamics
oral therapy
repurposing
Online Access:https://www.mdpi.com/1999-4923/16/12/1607
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