NADK tetramer defective mutants affect lung cancer response to chemotherapy via controlling NADK activity

NADK tetramer defective mutants affect lung cancer response to chemotherapy via controlling NADK activity

Nicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+ to generate NADP+, which plays a crucial role in maintaining NAD+/NADP+ homeostasis, cellular redox balance, and metabolism. However, how human NADK activity is regulated, and how dysregulation or mutation of NADK is linked t...

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Bibliographic Details
Main Authors: Mengxue Hu, Fuxing Wang, Yue Zhu, Yi Yao, Huadong Pei, Zheng Liu, Pingfeng Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-07-01
Series:Genes and Diseases
Subjects:
Chemotherapy resistance
Lung cancer
Methylation
NADK mutants
NADK tetramer
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304224003076
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