Mirodenafil improves cognitive function by reducing microglial activation and blood–brain barrier permeability in ApoE4 KI mice

Mirodenafil improves cognitive function by reducing microglial activation and blood–brain barrier permeability in ApoE4 KI mice

IntroductionAlzheimer’s disease (AD) has significant public health concerns in the aging society. AD can compromise brain function and lead to severe neurological abnormalities associated with dementia. The human Apolipoprotein E (ApoE4) gene is a strong risk factor for AD. However, comprehensive an...

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Bibliographic Details
Main Authors: Yejin Park, Subin Moon, Harry Jung, Songyi Park, Ju Won Kim, Dan-Gyeong Song, Yong-Ho In, Sang Won Han, Jong-Hee Sohn, Chan Hee Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
human Apolipoprotein E
cerebrovascular perfusion
cognitive function
mirodenafil
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1579411/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1579411/full

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