TRF2 interaction with nuclear envelope is required for cell polarization and metastasis in triple negative breast cancer

TRF2 interaction with nuclear envelope is required for cell polarization and metastasis in triple negative breast cancer

Abstract The Telomere Repeat-Binding factor 2 (TRF2) contributes to cancer progression by both telomere-dependent and independent mechanisms, including immune escape and angiogenesis. Here, we found that TRF2, through its Basic domain, directly interacts with Emerin forming a complex, including Lami...

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Main Authors: Eleonora Petti, Serena Di Vito, Roberto Dinami, Manuela Porru, Stefano Marchesi, Jeroen Lohuis, Pasquale Zizza, Sara Iachettini, Erica Salvati, Carmen D’Angelo, Angela Rizzo, Carmen Maresca, Flora Ascione, Anna Di Benedetto, Simonetta Buglioni, Andrea Sacconi, Paola Ostano, Qingsen Li, Antonella Stoppacciaro, Carlo Leonetti, Jacco van Rheenen, Paolo Maiuri, Giorgio Scita, Annamaria Biroccio
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07415-4
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https://doi.org/10.1038/s41419-025-07415-4

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