Maternal diabetes disrupts early corticogenesis through altered mitotic gene regulation: a transcriptomic analysis

Maternal diabetes disrupts early corticogenesis through altered mitotic gene regulation: a transcriptomic analysis

Maternal diabetes is linked to neurodevelopmental impairments in offspring, but the underlying molecular mechanisms remain unclear. Early cortical neurogenesis is a critical window vulnerable to maternal metabolic disturbances. Here, we analyzed global gene expression by RNA sequencing in dorsal pro...

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Main Authors: Rocío Valle-Bautista, Diana S. de la Merced-García, Dafne A. Díaz-Piña, Néstor Fabián Díaz, Daniela Ávila-González, Anayansi Molina-Hernández
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Endocrinology
Subjects:
maternal diabetes
embryo cortical transcriptome
corticogenesis
neural stem cells mitosis
achromatic spindle
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1564441/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1564441/full

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