In vivo antiviral efficacy of LCTG-002, a pooled, purified human milk secretory IgA product, against SARS-CoV-2 in a murine model of COVID-19

In vivo antiviral efficacy of LCTG-002, a pooled, purified human milk secretory IgA product, against SARS-CoV-2 in a murine model of COVID-19

Immunoglobulin A (IgA) is the most abundant antibody (Ab) in human mucosae, with secretory form (sIgA) being dominant and uniquely stable. sIgA is challenging to produce recombinantly but is naturally found in human milk, which could be considered a global resource for this biologic, justifying its...

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Bibliographic Details
Main Authors: Viraj Mane, Rikin Mehta, Nadine Alvarez, Vijeta Sharma, Steven Park, Alisa Fox, Claire DeCarlo, Xiaoqi Yang, David S. Perlin, Rebecca L. R. Powell
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Secretory IgA
human milk
mucosal infection
SARS-CoV-2
COVID-19
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2024.2303226
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https://www.tandfonline.com/doi/10.1080/21645515.2024.2303226

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