Anticancer activity of Stemona tuberosa (wild asparagus) against type-II human lung adenocarcinoma (A549) cells and identification of SRC inhibitor using integrated network pharmacology and molecular dynamic simulation

Anticancer activity of Stemona tuberosa (wild asparagus) against type-II human lung adenocarcinoma (A549) cells and identification of SRC inhibitor using integrated network pharmacology and molecular dynamic simulation

Abstract Stemona tuberosa is widely recognized for its traditional applications as an anti-cancer agent. This study aimed to assess the anti-cancer properties of S. tuberosa in human lung adenocarcinoma A549 cells. Among the various solvent extracts of S. tuberosa, the methanolic extract showed the...

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Main Authors: C. Lalmuansangi, Lalfakawmi, Fanai Nghakliana, Hmingremhlua Sailo, Lalchhandami Tochhawng, Amit Kumar Trivedi, Kiran R. Kharat, Balachandar Vellingiri, Nachimuthu Senthil Kumar, Zothan Siama
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Discover Oncology
Subjects:
Stemona tuberosa
Cytotoxicity
DNA damage
Apoptotic genes
Molecular docking
Molecular dynamics (MD) simulation
Online Access:https://doi.org/10.1007/s12672-025-02138-6
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https://doi.org/10.1007/s12672-025-02138-6

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