Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives
New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the b...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/982404 |
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| author | Mohammed El Fal Youssef Ramli Abdelfettah Zerzouf Ahmed Talbaoui Youssef Bakri El Mokhtar Essassi |
| author_facet | Mohammed El Fal Youssef Ramli Abdelfettah Zerzouf Ahmed Talbaoui Youssef Bakri El Mokhtar Essassi |
| author_sort | Mohammed El Fal |
| collection | DOAJ |
| description | New heterocyclic compounds spiroderivatives of
allopurinol of biological interest were prepared from
allopurinol via thionation and 1,3-dipolar
cycloaddition and were produced in high to excellent
yields. These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR, 13C, IR, and MS).
The antibacterial activity of the synthesized products was studied
using bacterial strains: Staphylococcus aureus,
Enterococcus faecalis, Escherichia
coli, and Pseudomonas aeruginosa.
Compounds having an ethyl group showed the best activity with MIC
value of 31.25 µg/mL against Staphylococcus
aureus and Streptococcus fasciens. |
| format | Article |
| id | doaj-art-14fc71a9907a491f9e0ca534e786b61a |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-14fc71a9907a491f9e0ca534e786b61a2025-02-03T01:23:19ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/982404982404Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] DerivativesMohammed El Fal0Youssef Ramli1Abdelfettah Zerzouf2Ahmed Talbaoui3Youssef Bakri4El Mokhtar Essassi5Laboratoire de Chimie Organique Hétérocyclique URAC 21, Faculté des Sciences, Université Mohammed V, Rabat, MoroccoMedicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10170 Rabat, MoroccoLaboratoire de Physico-Chimie des Matériaux Inorganiques et Organiques (LPCMIO), ENS, Rabat, MoroccoLaboratoire de Biochimie et Immunologie, Faculté des Sciences, Université Mohammed V, Rabat, MoroccoLaboratoire de Biochimie et Immunologie, Faculté des Sciences, Université Mohammed V, Rabat, MoroccoLaboratoire de Chimie Organique Hétérocyclique URAC 21, Faculté des Sciences, Université Mohammed V, Rabat, MoroccoNew heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR, 13C, IR, and MS). The antibacterial activity of the synthesized products was studied using bacterial strains: Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. Compounds having an ethyl group showed the best activity with MIC value of 31.25 µg/mL against Staphylococcus aureus and Streptococcus fasciens.http://dx.doi.org/10.1155/2015/982404 |
| spellingShingle | Mohammed El Fal Youssef Ramli Abdelfettah Zerzouf Ahmed Talbaoui Youssef Bakri El Mokhtar Essassi Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives Journal of Chemistry |
| title | Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives |
| title_full | Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives |
| title_fullStr | Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives |
| title_full_unstemmed | Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives |
| title_short | Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives |
| title_sort | synthesis and antibacterial activity of new spiro thiadiazoline pyrazolo 3 4 d pyrimidine derivatives |
| url | http://dx.doi.org/10.1155/2015/982404 |
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