hiPSC-derived cardiac fibroblasts dynamically enhance the mechanical function of hiPSC-derived cardiomyocytes on an engineered substrate

hiPSC-derived cardiac fibroblasts dynamically enhance the mechanical function of hiPSC-derived cardiomyocytes on an engineered substrate

IntroductionCardiac fibroblasts deposit and turnover the extracellular matrix in the heart, as well as secrete soluble factors that play critical roles in development, homeostasis, and disease. Coculture of CFs and human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) enhances CM...

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Bibliographic Details
Main Authors: Mitchell Josvai, Jodi Lawson, Harshal Kanade, Meghana Kalluri, Corey L. Anderson, Jianhua Zhang, Alana Stempien, Lee L. Eckhardt, Timothy J. Kamp, Wendy C. Crone
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
hiPSC
cardiomyocytes
cardiac fibroblasts
mechanical function
tissue engineering
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1546483/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1546483/full

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