Biotin's protective effects against nicotine withdrawal-induced anxiety and depression: Mechanistic insights into serotonin, inflammation, BDNF, and oxidative stress in male rats

Biotin's protective effects against nicotine withdrawal-induced anxiety and depression: Mechanistic insights into serotonin, inflammation, BDNF, and oxidative stress in male rats

Introduction: Substance use disorders, particularly nicotine use disorders, represent a significant public health problem, with adolescents particularly vulnerable to their adverse effects. This study examined the potential anxiolytic and antidepressant effects of biotin in attenuating the behaviora...

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Bibliographic Details
Main Authors: Dawood Hossaini, Mohammad Jalal Nazari, Khan Baba Ghazanfar, Mohammad Edris Amiri, Mohammad Tariq Anwary, Mohammad Jawad Jawad, Murtaza Haidary
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Addiction Neuroscience
Subjects:
Adolescents
Nicotine withdrawal
Anxiety
Depression
Cortex
Online Access:http://www.sciencedirect.com/science/article/pii/S2772392525000057
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