Clinical Characteristics in Patients with Triple Negative Breast Cancer
Purpose. The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis. Methods. Our institutional database was queried for al...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2017/1796145 |
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| _version_ | 1832565423532408832 |
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| author | Janet Yeh Jennifer Chun Shira Schwartz Annie Wang Elizabeth Kern Amber A. Guth Deborah Axelrod Richard Shapiro Freya Schnabel |
| author_facet | Janet Yeh Jennifer Chun Shira Schwartz Annie Wang Elizabeth Kern Amber A. Guth Deborah Axelrod Richard Shapiro Freya Schnabel |
| author_sort | Janet Yeh |
| collection | DOAJ |
| description | Purpose. The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis. Methods. Our institutional database was queried for all patients diagnosed with invasive breast cancer between January 2010 and May 2016. Results. Out of a total of 1964 patients, 190 (10%) patients had TNBC. The median age for both TNBC and non-TNBC was 59 years. There was a significantly higher proportion of African American and Asian patients with TNBC (p=0.0003) compared to patients with non-TNBC. BRCA1 and BRCA2 were significantly associated with TNBC (p<0.0001, p=0.0007). A prior history of breast cancer was significantly associated with TNBC (p=0.0003). There was no relationship observed between TNBC and a history of chemoprevention or patients who had a history of AH or LCIS. Conclusions. We found that having Asian ancestry, a prior history of breast cancer, and a BRCA1 or BRCA2 mutation all appear to be positively associated with TNBC. In order to develop more effective treatments, better surveillance, and improved prevention strategies, it is necessary to improve our understanding of the population at risk for TNBC. |
| format | Article |
| id | doaj-art-14c758b7f94c4cbc9d6d6bcdbd903135 |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-14c758b7f94c4cbc9d6d6bcdbd9031352025-02-03T01:07:44ZengWileyInternational Journal of Breast Cancer2090-31702090-31892017-01-01201710.1155/2017/17961451796145Clinical Characteristics in Patients with Triple Negative Breast CancerJanet Yeh0Jennifer Chun1Shira Schwartz2Annie Wang3Elizabeth Kern4Amber A. Guth5Deborah Axelrod6Richard Shapiro7Freya Schnabel8Department of Surgery, New York University Langone Medical Center, New York, NY, USADepartment of Surgery, New York University Langone Medical Center, New York, NY, USADepartment of Surgery, New York University Langone Medical Center, New York, NY, USASchool of Medicine, New York University Langone Medical Center, New York, NY, USADrexel University, School of Medicine, Philadelphia, PA, USADepartment of Surgery, New York University Langone Medical Center, New York, NY, USADepartment of Surgery, New York University Langone Medical Center, New York, NY, USADepartment of Surgery, New York University Langone Medical Center, New York, NY, USADepartment of Surgery, New York University Langone Medical Center, New York, NY, USAPurpose. The purpose of this study was to compare and contrast the clinical characteristics of the triple negative breast cancer (TNBC) and non-TNBC patients, with a particular focus on genetic susceptibility and risk factors prior to diagnosis. Methods. Our institutional database was queried for all patients diagnosed with invasive breast cancer between January 2010 and May 2016. Results. Out of a total of 1964 patients, 190 (10%) patients had TNBC. The median age for both TNBC and non-TNBC was 59 years. There was a significantly higher proportion of African American and Asian patients with TNBC (p=0.0003) compared to patients with non-TNBC. BRCA1 and BRCA2 were significantly associated with TNBC (p<0.0001, p=0.0007). A prior history of breast cancer was significantly associated with TNBC (p=0.0003). There was no relationship observed between TNBC and a history of chemoprevention or patients who had a history of AH or LCIS. Conclusions. We found that having Asian ancestry, a prior history of breast cancer, and a BRCA1 or BRCA2 mutation all appear to be positively associated with TNBC. In order to develop more effective treatments, better surveillance, and improved prevention strategies, it is necessary to improve our understanding of the population at risk for TNBC.http://dx.doi.org/10.1155/2017/1796145 |
| spellingShingle | Janet Yeh Jennifer Chun Shira Schwartz Annie Wang Elizabeth Kern Amber A. Guth Deborah Axelrod Richard Shapiro Freya Schnabel Clinical Characteristics in Patients with Triple Negative Breast Cancer International Journal of Breast Cancer |
| title | Clinical Characteristics in Patients with Triple Negative Breast Cancer |
| title_full | Clinical Characteristics in Patients with Triple Negative Breast Cancer |
| title_fullStr | Clinical Characteristics in Patients with Triple Negative Breast Cancer |
| title_full_unstemmed | Clinical Characteristics in Patients with Triple Negative Breast Cancer |
| title_short | Clinical Characteristics in Patients with Triple Negative Breast Cancer |
| title_sort | clinical characteristics in patients with triple negative breast cancer |
| url | http://dx.doi.org/10.1155/2017/1796145 |
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