Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction
Abstract Myocardial infarction (MI) causes the loss of millions of cardiomyocytes, and current treatments do not address this root issue. New therapies focus on stimulating cardiomyocyte division in the adult heart, inspired by the regenerative capacities of lower vertebrates and neonatal mice. This...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Regenerative Medicine |
| Online Access: | https://doi.org/10.1038/s41536-025-00394-2 |
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| _version_ | 1832585967094988800 |
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| author | Axelle Bois Catarina Grandela James Gallant Christine Mummery Philippe Menasché |
| author_facet | Axelle Bois Catarina Grandela James Gallant Christine Mummery Philippe Menasché |
| author_sort | Axelle Bois |
| collection | DOAJ |
| description | Abstract Myocardial infarction (MI) causes the loss of millions of cardiomyocytes, and current treatments do not address this root issue. New therapies focus on stimulating cardiomyocyte division in the adult heart, inspired by the regenerative capacities of lower vertebrates and neonatal mice. This review explores strategies for heart regeneration, offers insights into cardiomyocyte proliferation, evaluates in vivo models, and discusses integrating in vitro human cardiac models to advance cardiac regeneration research. |
| format | Article |
| id | doaj-art-14c6e1a637634fb9adcc75dff09b1d59 |
| institution | Kabale University |
| issn | 2057-3995 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Regenerative Medicine |
| spelling | doaj-art-14c6e1a637634fb9adcc75dff09b1d592025-01-26T12:19:07ZengNature Portfolionpj Regenerative Medicine2057-39952025-01-0110111510.1038/s41536-025-00394-2Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarctionAxelle Bois0Catarina Grandela1James Gallant2Christine Mummery3Philippe Menasché4Department of Anatomy and Embryology, Leiden University Medical CenterDepartment of Anatomy and Embryology, Leiden University Medical CenterDepartment of Anatomy and Embryology, Leiden University Medical CenterDepartment of Anatomy and Embryology, Leiden University Medical CenterDepartment of Cardiovascular Surgery, Université Paris Cité, INSERM U970, PARCC Hôpital Européen Georges PompidouAbstract Myocardial infarction (MI) causes the loss of millions of cardiomyocytes, and current treatments do not address this root issue. New therapies focus on stimulating cardiomyocyte division in the adult heart, inspired by the regenerative capacities of lower vertebrates and neonatal mice. This review explores strategies for heart regeneration, offers insights into cardiomyocyte proliferation, evaluates in vivo models, and discusses integrating in vitro human cardiac models to advance cardiac regeneration research.https://doi.org/10.1038/s41536-025-00394-2 |
| spellingShingle | Axelle Bois Catarina Grandela James Gallant Christine Mummery Philippe Menasché Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction npj Regenerative Medicine |
| title | Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction |
| title_full | Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction |
| title_fullStr | Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction |
| title_full_unstemmed | Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction |
| title_short | Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction |
| title_sort | revitalizing the heart strategies and tools for cardiomyocyte regeneration post myocardial infarction |
| url | https://doi.org/10.1038/s41536-025-00394-2 |
| work_keys_str_mv | AT axellebois revitalizingtheheartstrategiesandtoolsforcardiomyocyteregenerationpostmyocardialinfarction AT catarinagrandela revitalizingtheheartstrategiesandtoolsforcardiomyocyteregenerationpostmyocardialinfarction AT jamesgallant revitalizingtheheartstrategiesandtoolsforcardiomyocyteregenerationpostmyocardialinfarction AT christinemummery revitalizingtheheartstrategiesandtoolsforcardiomyocyteregenerationpostmyocardialinfarction AT philippemenasche revitalizingtheheartstrategiesandtoolsforcardiomyocyteregenerationpostmyocardialinfarction |