Rational design of FVIII sialylated peptides to target Siglec-3 and Siglec-9 and improve peptide formulations for reverse vaccines

Rational design of FVIII sialylated peptides to target Siglec-3 and Siglec-9 and improve peptide formulations for reverse vaccines

Reverse vaccine formulations have shown their potential for the treatment of allergies and other autoimmune diseases by the design of antigens that modify dendritic cell function towards tolerogenic responses. We here demonstrate that modification of an immunodominant peptide from factor VIII (FVIII...

Full description

Saved in:
Bibliographic Details
Main Authors: Eleonora Nardini, Brigitte-Carole Keumatio Doungstop, Tania Gerpe-Amor, Aram M. de Haas, Mike de Kok, Evert Peterse, Hakan Kalay, Rui-Jún E. Li, Fabrizio Chiodo, Alba Silipo, Jan Voorberg, Yvette van Kooyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
hemophilia a
FVIII
inhibitors
sialic acid
siglec-9
peptide immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1558627/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2025.1558627/full

Similar Items