A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution

A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by exceedingly high rates of metastatic progression, with the liver representing the most common site of distant spread. Here, we established a platform for multisite immune profiling of human PDAC encompassing the tumor, p...

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Main Authors: Elishama N. Kanu, Ashley A. Fletcher, Jiayin Bao, Ethan S. Agritelley, Julia Button, Austin M. Eckhoff, Karrie Comatas, Tao Wang, Bin-Jin Hwang, Michael E. Lidsky, Sabino Zani, Dan G. Blazer, Peter J. Allen, Zhicheng Ji, Frank J. Lowery, Sri Krishna, Nicholas D. Klemen, Daniel P. Nussbaum, Erika J. Crosby
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Single cell RNAseq
PDAC
Pre-metastatic liver
TCR
T cell clonality
Online Access:https://doi.org/10.1007/s00262-025-04146-5
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https://doi.org/10.1007/s00262-025-04146-5

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