In Silico and In Vitro Studies of the Approved Antibiotic Ceftaroline Fosamil and Its Metabolites as Inhibitors of SARS-CoV-2 Replication

In Silico and In Vitro Studies of the Approved Antibiotic Ceftaroline Fosamil and Its Metabolites as Inhibitors of SARS-CoV-2 Replication

The SARS-CoV-2 proteases M<sup>pro</sup> and PL<sup>pro</sup> are critical targets for antiviral drug development for the treatment of COVID-19. The 1,2,4-thiadiazole functional group is an inhibitor of cysteine proteases, such as papain and cathepsins. This chemical moiety i...

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Main Authors: Cássia Delgado, Pablo Andrei Nogara, Milene Dias Miranda, Alice Santos Rosa, Vivian Neuza Santos Ferreira, Luisa Tozatto Batista, Thamara Kelcya Fonseca Oliveira, Folorunsho Bright Omage, Flávia Motta, Izabela Marques Bastos, Laura Orian, João Batista Teixeira Rocha
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Viruses
Subjects:
cysteine proteases
drug repurposing
ceftaroline fosamil
viral replication inhibition
SARS-CoV-2
molecular docking
Online Access:https://www.mdpi.com/1999-4915/17/4/491
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