Cellular imbalance in proximal and distal lung of CFTR −/− sheep in utero and at birth

Cellular imbalance in proximal and distal lung of CFTR −/− sheep in utero and at birth

Abstract Background The Lung is the major focus of therapeutic approaches for the inherited disorder cystic fibrosis (CF) as without treatment lung disease is life-limiting. However, the initiating events that predispose the CF lung to cycles of infection, inflammation and resultant tissue damage ar...

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Main Authors: Shih-Hsing Leir, Svyatoslav Tkachenko, Alekh Paranjapye, Arnaud J. Van Wettere, Jenny L. Kerschner, Iuri Viotti Perisse, Cheyenne M. Marriott, Tayler Patrick, Ying Liu, Kenneth L. White, Irina A. Polejaeva, Ann Harris
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
Cystic fibrosis (CF)
In utero
Lung development
ScRNA-seq
Ciliated cells
Online Access:https://doi.org/10.1186/s10020-025-01266-7
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https://doi.org/10.1186/s10020-025-01266-7

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