Type 2 gene expression signature in severe asthma associates with more advanced airway remodeling

Type 2 gene expression signature in severe asthma associates with more advanced airway remodeling

Abstract Background Asthma is a heterogeneous disease with various inflammatory subtypes, including the type‐2 (T2) endotype associated with airway eosinophilia. Severe asthma is linked to reduced ventilatory function due to airway structural changes. This study compared the extent of airway remodel...

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Main Authors: Bogdan Jakiela, Karolina Górka, Iwona Gross‐Sondej, Sławomir Mikrut, Krzysztof Okoń, Piotr Sadowski, Anna Andrychiewicz, Hanna Plutecka, Tomasz Stachura, Grażyna Bochenek, Stanisława Bazan‐Socha, Krzysztof Sładek, Jerzy Soja
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Clinical and Translational Allergy
Subjects:
airway remodeling
asthma endotypes
endobronchial ultrasound
severe asthma
type 2 immunity
Online Access:https://doi.org/10.1002/clt2.70060
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https://doi.org/10.1002/clt2.70060

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