Immunohistochemical detection of 5-hydroxymethylcytosine as a prognostic biomarker in non-WNT/Non-SHH medulloblastomas

Immunohistochemical detection of 5-hydroxymethylcytosine as a prognostic biomarker in non-WNT/Non-SHH medulloblastomas

Abstract Although reduced levels of global 5-hydroxymethylcytosine (5hmC) have been observed in medulloblastomas (MBs), it remains unclear whether immunohistochemical (IHC) evaluation of 5hmC can serve as a prognostic biomarker for patients with MB. We performed IHC staining using a 5hmC antibody on...

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Bibliographic Details
Main Authors: Han-Guang Zhao, Si-kang Ren, Wen-Tao Zhou, Zhi‑Ming Liu, Lei-Ming Wang, Yong-ji Tian, Fu Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Medulloblastoma
5hmC
Prognosis
Biomarker
Immunohistochemistry
Online Access:https://doi.org/10.1038/s41598-025-00052-z
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https://doi.org/10.1038/s41598-025-00052-z

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