Glucosamine induces hepatic FGF21 expression by activating the Akt/mTOR/p70S6K axis and driving PGC-1α activity

Glucosamine induces hepatic FGF21 expression by activating the Akt/mTOR/p70S6K axis and driving PGC-1α activity

Abstract Glucosamine (GlcN) is a common supplement used to alleviate osteoarthritis, but it may dysregulate glucose tolerance and induce insulin resistance, thereby increasing metabolic burden. The liver is a vital organ that modulates the Akt/mTOR/p70S6K signaling pathway in response to growth and...

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Bibliographic Details
Main Authors: Shui-Yu Liu, Luen-Kui Chen, Pin-Hsuan Li, Guan-Lin Wu, Tsung-Hui Wu, Yuan-Bin Yu, Heng-Fu Lin, Chi-Chang Juan
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Glucosamine
Diabetes
Hepatocyte
FGF21
PGC-1α
Online Access:https://doi.org/10.1038/s41598-025-96249-3
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https://doi.org/10.1038/s41598-025-96249-3

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