Rationale and design of the GLADE study: a randomized, multicenter, double-blind, placebo-controlled trial evaluating the safety and efficacy of gestrinone subdermal bioabsorbable pellet in endometriosis-related pelvic pain

Rationale and design of the GLADE study: a randomized, multicenter, double-blind, placebo-controlled trial evaluating the safety and efficacy of gestrinone subdermal bioabsorbable pellet in endometriosis-related pelvic pain

Background Pelvic pain secondary to endometriosis is a disabling condition. There are multiple treatments available, with variable endpoints. No prospective controlled studies were carried out evaluating subdermal pellets of gestrinone in this population.Methods One hundred participants with documen...

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Main Authors: André Malavasi, Camilla Moreira Ribeiro, Leandro Barile Agati, Agnaldo Silva Filho, Charles Berger, Eduardo Schor, Ana Comin, Eduardo José Bezerra Neto, Taís Helena de Oliveira, Polyana Raposo Caldas, Francisco Lopes, Nathalia Westphalen, Francisleny Vieira, Eduardo Augusto Rabelo Socca, Daniele Komar, Eduardo Ramacciotti
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Annals of Medicine
Subjects:
Endometriosis
pelvic pain
subcutaneous pellet
gestrinone
R-2323
Online Access:https://www.tandfonline.com/doi/10.1080/07853890.2025.2527352
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https://www.tandfonline.com/doi/10.1080/07853890.2025.2527352

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