Baseline profile peripheral Tfh cells predict immune-related adverse events in immune checkpoint inhibitor therapy of gastrointestinal cancer

Baseline profile peripheral Tfh cells predict immune-related adverse events in immune checkpoint inhibitor therapy of gastrointestinal cancer

BackgroundImmune checkpoint inhibitors (ICIs) have transformed cancer therapy but are limited by immune-related adverse events (irAEs). This study aimed to assess peripheral T cell profiles to identify irAEs biomarkers and construct predictive models.MethodsIn our study, we enrolled and followed 51...

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Main Authors: Yifan Wang, Zhening Zhang, Tong Xie, Yudong Liu, Cheng Zhang, Hao Li, Ruiling Feng, Bo Huang, Qinghong Liu, Naidi Wang, Xiaoyan Xing, Yipeng Han, Xue Li, Ruoyi Wang, Jing He, Zhi Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint inhibitors
immune-related adverse events
gastrointestinal cancer
T cell subsets
Tfh cells
Tph cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1559275/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1559275/full

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