Restoring immune tolerance in pre-RA: immunometabolic dialogue between gut microbiota and regulatory T cells
Rheumatoid arthritis (RA) is a complex chronic autoimmune disease that remains incurable for most patients. With advances in our understanding of the disease’s natural history, the concept of pre-RA has emerged as a window of opportunity to intervene before irreversible joint damage occurs. Numerous...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565133/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850059837286645760 |
|---|---|
| author | Anqi Gao Anqi Gao Anqi Gao Ruihe Wu Ruihe Wu Ruihe Wu Yanfei Mu Yanfei Mu Yanfei Mu Ruqing Jin Ruqing Jin Ruqing Jin Saixin Jiang Saixin Jiang Saixin Jiang Chong Gao Xiaofeng Li Xiaofeng Li Xiaofeng Li Caihong Wang Caihong Wang Caihong Wang |
| author_facet | Anqi Gao Anqi Gao Anqi Gao Ruihe Wu Ruihe Wu Ruihe Wu Yanfei Mu Yanfei Mu Yanfei Mu Ruqing Jin Ruqing Jin Ruqing Jin Saixin Jiang Saixin Jiang Saixin Jiang Chong Gao Xiaofeng Li Xiaofeng Li Xiaofeng Li Caihong Wang Caihong Wang Caihong Wang |
| author_sort | Anqi Gao |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a complex chronic autoimmune disease that remains incurable for most patients. With advances in our understanding of the disease’s natural history, the concept of pre-RA has emerged as a window of opportunity to intervene before irreversible joint damage occurs. Numerous studies have indicated that the key step driving autoimmunity in early pre-RA lies at an extra-articular site, which is closely related to the regulatory T (Treg) cell-established immune tolerance to the gut microbiota. The intricate immunometabolic crosstalk between Treg cells and the gut microbiota is beginning to be understood, with the re-recognition of Treg cells as metabolic sensors in recent years. In the future, deciphering their immunometabolic dialogue may help to elucidate the underlying mechanisms of pre-RA. Identifying novel biological pathways in the pre-RA stage will bring insights into restoring immune tolerance, thereby potentially curing or preventing the onset of RA. |
| format | Article |
| id | doaj-art-1438fc5156b14cfa973c7fdbe2e1d6a2 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-1438fc5156b14cfa973c7fdbe2e1d6a22025-08-20T02:50:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-03-011610.3389/fimmu.2025.15651331565133Restoring immune tolerance in pre-RA: immunometabolic dialogue between gut microbiota and regulatory T cellsAnqi Gao0Anqi Gao1Anqi Gao2Ruihe Wu3Ruihe Wu4Ruihe Wu5Yanfei Mu6Yanfei Mu7Yanfei Mu8Ruqing Jin9Ruqing Jin10Ruqing Jin11Saixin Jiang12Saixin Jiang13Saixin Jiang14Chong Gao15Xiaofeng Li16Xiaofeng Li17Xiaofeng Li18Caihong Wang19Caihong Wang20Caihong Wang21Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Precision Medical Engineering Research Center for Rheumatology, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Precision Medical Engineering Research Center for Rheumatology, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Precision Medical Engineering Research Center for Rheumatology, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Precision Medical Engineering Research Center for Rheumatology, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Precision Medical Engineering Research Center for Rheumatology, Taiyuan, Shanxi, ChinaPathology, Joint Program in Transfusion Medicine, Brigham and Women’s Hospital/Children’s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Precision Medical Engineering Research Center for Rheumatology, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Key Laboratory of Rheumatism Immune Microecology, Taiyuan, Shanxi, ChinaDepartment of Rheumatology, Shanxi Precision Medical Engineering Research Center for Rheumatology, Taiyuan, Shanxi, ChinaRheumatoid arthritis (RA) is a complex chronic autoimmune disease that remains incurable for most patients. With advances in our understanding of the disease’s natural history, the concept of pre-RA has emerged as a window of opportunity to intervene before irreversible joint damage occurs. Numerous studies have indicated that the key step driving autoimmunity in early pre-RA lies at an extra-articular site, which is closely related to the regulatory T (Treg) cell-established immune tolerance to the gut microbiota. The intricate immunometabolic crosstalk between Treg cells and the gut microbiota is beginning to be understood, with the re-recognition of Treg cells as metabolic sensors in recent years. In the future, deciphering their immunometabolic dialogue may help to elucidate the underlying mechanisms of pre-RA. Identifying novel biological pathways in the pre-RA stage will bring insights into restoring immune tolerance, thereby potentially curing or preventing the onset of RA.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565133/fullrheumatoid arthritispre-RAregulatory T cellgut microbiotaimmunometabolism |
| spellingShingle | Anqi Gao Anqi Gao Anqi Gao Ruihe Wu Ruihe Wu Ruihe Wu Yanfei Mu Yanfei Mu Yanfei Mu Ruqing Jin Ruqing Jin Ruqing Jin Saixin Jiang Saixin Jiang Saixin Jiang Chong Gao Xiaofeng Li Xiaofeng Li Xiaofeng Li Caihong Wang Caihong Wang Caihong Wang Restoring immune tolerance in pre-RA: immunometabolic dialogue between gut microbiota and regulatory T cells Frontiers in Immunology rheumatoid arthritis pre-RA regulatory T cell gut microbiota immunometabolism |
| title | Restoring immune tolerance in pre-RA: immunometabolic dialogue between gut microbiota and regulatory T cells |
| title_full | Restoring immune tolerance in pre-RA: immunometabolic dialogue between gut microbiota and regulatory T cells |
| title_fullStr | Restoring immune tolerance in pre-RA: immunometabolic dialogue between gut microbiota and regulatory T cells |
| title_full_unstemmed | Restoring immune tolerance in pre-RA: immunometabolic dialogue between gut microbiota and regulatory T cells |
| title_short | Restoring immune tolerance in pre-RA: immunometabolic dialogue between gut microbiota and regulatory T cells |
| title_sort | restoring immune tolerance in pre ra immunometabolic dialogue between gut microbiota and regulatory t cells |
| topic | rheumatoid arthritis pre-RA regulatory T cell gut microbiota immunometabolism |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565133/full |
| work_keys_str_mv | AT anqigao restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT anqigao restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT anqigao restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT ruihewu restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT ruihewu restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT ruihewu restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT yanfeimu restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT yanfeimu restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT yanfeimu restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT ruqingjin restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT ruqingjin restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT ruqingjin restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT saixinjiang restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT saixinjiang restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT saixinjiang restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT chonggao restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT xiaofengli restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT xiaofengli restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT xiaofengli restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT caihongwang restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT caihongwang restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells AT caihongwang restoringimmunetoleranceinpreraimmunometabolicdialoguebetweengutmicrobiotaandregulatorytcells |