Immunosuppressive cells in acute myeloid leukemia: mechanisms and therapeutic target

Immunosuppressive cells in acute myeloid leukemia: mechanisms and therapeutic target

Immunotherapy has emerged as a cornerstone strategy for augmenting therapeutic efficacy in acute myeloid leukemia (AML). The immunosuppressive AML microenvironment, characterized by profound immune dysfunction, critically impairs anti-leukemic immune surveillance. This immunologically hostile niche...

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Main Authors: Mengnan Liu, Mengting Yang, Yue Qi, Yuting Ma, Qulian Guo, Ling Guo, Chunyan Liu, Wenjun Liu, Lan Xiao, You Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
acute myeloid leukemia
regulatory T cells
regulatory B cells
myeloid-derived suppressor cells
leukemia-associated macrophages
leukemia-associated neutrophils
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1627161/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1627161/full

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