Therapeutic potential of human mesenchymal stromal cell-derived mitochondria in a rat model of surgical digestive fistula

Therapeutic potential of human mesenchymal stromal cell-derived mitochondria in a rat model of surgical digestive fistula

Abstract Mitochondria are central to cellular energy metabolism and play a critical role in tissue regeneration. Mitochondrial dysfunction contributes to a range of degenerative conditions and impaired wound healing, driving increasing interest in mitochondrial transplantation as a novel therapeutic...

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Main Authors: Antoine Mariani, Augustin Guichard, Anna C. Sebbagh, André Cronemberger Andrade, Zahra Al Amir Dache, Christopher Ribes, Dmitry Ayollo, Mehdi Karoui, Gregory Lavieu, Florence Gazeau, Amanda K. A. Silva, Gabriel Rahmi, Sabah Mozafari
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Mitochondria transplantation
Post-surgical fistula
Human mesenchymal stromal cells (hMSCs)
Biotherapy
Wound healing, regenerative medicine
Online Access:https://doi.org/10.1038/s41598-025-13887-3
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https://doi.org/10.1038/s41598-025-13887-3

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