GDF11 restores the impaired function of EPCs-MA by promoting autophagy: GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy

GDF11 restores the impaired function of EPCs-MA by promoting autophagy: GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy

Our study aimed to assess the effects of Growth and differentiation factor 11 (GDF11) on the function of endothelial progenitor cells in middle-age individuals (EPCs-MA) isolated from mouse bone marrow and to explore the mechanistic relationship between GDF11 and age-related ALP impairment.

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Bibliographic Details
Main Authors: Liu Donghua, Zhang Yang, Liu Xin, Huang Qihe, Zhang Xiaofang, Yang Rui, Zhao Yue, Li Penghui, He Jiayi, Zhang Kexiao, Pan Zhenwei, Liu Huiwen, Yang Baofeng
Format: Article
Language:English
Published: De Gruyter 2025-01-01
Series:Frigid Zone Medicine
Subjects:
gdf11
endothelial progenitor cells
autophagy lysosome pathway
aging
Online Access:https://doi.org/10.1515/fzm-2024-0021
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Internet

https://doi.org/10.1515/fzm-2024-0021

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