KCNQ4 c.546C>G variant is associated with early-onset high-frequency hearing loss, tinnitus, and cardiovascular comorbidities in Taiwanese adults

KCNQ4 c.546C>G variant is associated with early-onset high-frequency hearing loss, tinnitus, and cardiovascular comorbidities in Taiwanese adults

Abstract KCNQ4 encodes a voltage-gated potassium channel essential for ion balance and membrane potential regulation in inner ear hair cells. Mutations in KCNQ4 are associated with late-onset, high-frequency hearing loss that progressively worsens. This study aimed to compare carriers of the KCNQ4 c...

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Bibliographic Details
Main Authors: Kuan-Liang Wu, Ting-Gang Chang, Yi-Ming Chen, I-Chieh Chen, Chiann-Yi Hsu, Ting-Ting Yen
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Autosomal dominant nonsyndromic hearing loss
KCNQ4 c.546C>G
High-frequency hearing loss
Tinnitus
Cardiovascular disease
Online Access:https://doi.org/10.1038/s41598-025-02992-y
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https://doi.org/10.1038/s41598-025-02992-y

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