Roles of JAK-STAT signaling and granulocyte–macrophage colony-stimulating factor in the development of osteitis and bone microstructure changes in rheumatoid arthritis

Roles of JAK-STAT signaling and granulocyte–macrophage colony-stimulating factor in the development of osteitis and bone microstructure changes in rheumatoid arthritis

Abstract Background Osteitis on magnetic resonance imaging (MRI) and bone microstructure changes (BMC) on high-resolution peripheral quantitative computed tomography (CT) are the earliest signs of arthritis, preceding the development of bone erosion on X-ray in rheumatoid arthritis (RA). Recently, a...

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Main Authors: Tsuneyasu Yoshida, Yoshiki Murotani, Koichi Murata, Hirohiko Imai, Takeshi Iwasaki, Yoichi Nakayama, Masao Katsushima, Mirei Shirakashi, Ran Nakashima, Ryu Watanabe, Kosaku Murakami, Hajime Yoshifuji, Akio Morinobu, Motomu Hashimoto
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Arthritis Research & Therapy
Online Access:https://doi.org/10.1186/s13075-025-03597-6
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https://doi.org/10.1186/s13075-025-03597-6

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