Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.

<h4>Background</h4>Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk pr...

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Main Authors: Rahul S Desikan, Chun Chieh Fan, Yunpeng Wang, Andrew J Schork, Howard J Cabral, L Adrienne Cupples, Wesley K Thompson, Lilah Besser, Walter A Kukull, Dominic Holland, Chi-Hua Chen, James B Brewer, David S Karow, Karolina Kauppi, Aree Witoelar, Celeste M Karch, Luke W Bonham, Jennifer S Yokoyama, Howard J Rosen, Bruce L Miller, William P Dillon, David M Wilson, Christopher P Hess, Margaret Pericak-Vance, Jonathan L Haines, Lindsay A Farrer, Richard Mayeux, John Hardy, Alison M Goate, Bradley T Hyman, Gerard D Schellenberg, Linda K McEvoy, Ole A Andreassen, Anders M Dale
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-03-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1002258
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https://doi.org/10.1371/journal.pmed.1002258

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