The potential role of adjunctive ascorbic acid in the prevention of colistin-induced nephrotoxicity in critically ill patients: A retrospective study

The potential role of adjunctive ascorbic acid in the prevention of colistin-induced nephrotoxicity in critically ill patients: A retrospective study

Background: Colistin is considered a valuable and last-resort therapeutic option for MDR gram-negative bacteria. Nephrotoxicity is the most clinically pertinent adverse effect of colistin. Vivo studies suggest that administering oxidative stress-reducing agents, such as ascorbic acid, is a promising...

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Main Authors: Khalid Al Sulaiman, Ohoud Aljuhani, Abdullah M. Alhammad, Kholoud Al Aamer, Sara Alshehri, Abdulmohsen Alhuwahmel, Abdullah Kharbosh, Areej Alshehri, Hanan Alshareef, Ibrahim Al Sulaihim, Albandari Alghamdi, Shmeylan Al Harbi, Ramesh Vishwakarma, Numan Alabdan, Yousef Alrajhi, Abdulmalik Al Katheri, Abeer A. Alenazi, Mai Alalawi, Ghassan Al Ghamdi
Format: Article
Language:English
Published: Springer 2022-12-01
Series:Saudi Pharmaceutical Journal
Subjects:
Colistin
Ascorbic Acid
Vitamin C
Nephrotoxicity
Colistin-induced nephrotoxicity
Mortality
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016422002511
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