FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries

FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries

Abstract Known fetal haemoglobin (HbF)-modulating loci explain 10–24% variation of HbF level in Africans with Sickle Cell Disease (SCD), compared to 50% among Europeans. Here, we report fourteen candidate loci from a genome-wide association study (GWAS) of HbF level in patients with SCD from Cameroo...

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Main Authors: Ambroise Wonkam, Kevin Esoh, Rachel M. Levine, Valentina Josiane Ngo Bitoungui, Khuthala Mnika, Nikitha Nimmagadda, Erin A. D. Dempsey, Siana Nkya, Raphael Z. Sangeda, Victoria Nembaware, Jack Morrice, Fujr Osman, Michael A. Beer, Julie Makani, Nicola Mulder, Guillaume Lettre, Martin H. Steinberg, Rachel Latanich, James F. Casella, Daiana Drehmer, Dan E. Arking, Emile R. Chimusa, Jonathan S. Yen, Gregory A. Newby, Stylianos E. Antonarakis
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57413-5
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https://doi.org/10.1038/s41467-025-57413-5

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