OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway

OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway

Abstract Background Osteosarcoma (OS), the most prevalent primary malignant bone tumor in children and adolescents, arises from bone-forming mesenchymal cells. Despite advancements in surgical resection and neoadjuvant chemotherapy (cisplatin, doxorubicin, and methotrexate), chemotherapy resistance...

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Bibliographic Details
Main Authors: Zehang Zheng, Yunhao Zeng, Xing Bao, Chuang Huang, Fengjing Guo, Fei Xu, Zhengqiang Luo
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Osteosarcoma
Chemoresistance
OTULIN
GPX4
Apoptosis
Online Access:https://doi.org/10.1186/s13046-024-03249-8
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https://doi.org/10.1186/s13046-024-03249-8

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