Geometry based prediction of tau protein sites and motifs associated with misfolding and aggregation

Abstract Recent studies of tau proteins point to specific sites or motifs along the protein related to its misfolding and aggregation propensity, which is associated with neurodegenerative diseases of structure-dependent pathology. In this manuscript we employ topology and geometry to analyze the lo...

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Bibliographic Details
Main Authors: Masumi Sugiyama, Kenneth S. Kosik, Eleni Panagiotou
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-93304-x
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