Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome
Objective. Insulin resistance (IR) and ovarian and adrenal hyperandrogenism are a common finding in women with polycystic ovary syndrome (PCOS). The aim of the present study was to access possible differences in insulin resistance, gonadotropins, and androgens production in obese and nonobese PCOS w...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/620605 |
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| author | Luciana Tock Gláucia Carneiro Andrea Z. Pereira Sérgio Tufik Maria Teresa Zanella |
| author_facet | Luciana Tock Gláucia Carneiro Andrea Z. Pereira Sérgio Tufik Maria Teresa Zanella |
| author_sort | Luciana Tock |
| collection | DOAJ |
| description | Objective. Insulin resistance (IR) and ovarian and adrenal hyperandrogenism are a common finding in women with polycystic ovary syndrome (PCOS). The aim of the present study was to access possible differences in insulin resistance, gonadotropins, and androgens production in obese and nonobese PCOS women. Study Design. We studied 37 PCOS women (16 nonobese and 21 obese) and 18 nonobese controls. Fasting glucose, insulin, androgens, and gonadotropins levels were determined. Salivary cortisol was measured basal and in the morning after dexamethasone (DEX) 0.25 mg. Results. Nonobese PCOS women showed higher basal salivary cortisol and serum dehydroepiandrosterone sulfate and luteinizing hormone (LH) levels than controls and obese PCOS. These hormones levels did not differ between the obese and control groups. After DEX administration no differences were found between the three groups. In PCOS women, salivary cortisol levels showed negative correlation with BMI (r=-0.52; P=0.001) and insulin (r=-0.47; P=0.003) and positive correlation with LH (r=0.40; P=0.016). Conclusion. Our results show an increased adrenocortical production in nonobese PCOS women, not related to IR and associated with a normal hypothalamic-pituitary-adrenal suppression. Higher LH levels might be involved in this event. |
| format | Article |
| id | doaj-art-13d9630d336746c388e8dcfce8965d1c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-13d9630d336746c388e8dcfce8965d1c2025-02-03T01:03:27ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/620605620605Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary SyndromeLuciana Tock0Gláucia Carneiro1Andrea Z. Pereira2Sérgio Tufik3Maria Teresa Zanella4Division of Endocrinology, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, BrazilDivision of Endocrinology, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, BrazilDivision of Endocrinology, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, BrazilDepartment of Psychobiology, Sleep Disorders Center, Universidade Federal de São Paulo, São Paulo, SP, BrazilDivision of Endocrinology, Department of Medicine, Universidade Federal de São Paulo, São Paulo, SP, BrazilObjective. Insulin resistance (IR) and ovarian and adrenal hyperandrogenism are a common finding in women with polycystic ovary syndrome (PCOS). The aim of the present study was to access possible differences in insulin resistance, gonadotropins, and androgens production in obese and nonobese PCOS women. Study Design. We studied 37 PCOS women (16 nonobese and 21 obese) and 18 nonobese controls. Fasting glucose, insulin, androgens, and gonadotropins levels were determined. Salivary cortisol was measured basal and in the morning after dexamethasone (DEX) 0.25 mg. Results. Nonobese PCOS women showed higher basal salivary cortisol and serum dehydroepiandrosterone sulfate and luteinizing hormone (LH) levels than controls and obese PCOS. These hormones levels did not differ between the obese and control groups. After DEX administration no differences were found between the three groups. In PCOS women, salivary cortisol levels showed negative correlation with BMI (r=-0.52; P=0.001) and insulin (r=-0.47; P=0.003) and positive correlation with LH (r=0.40; P=0.016). Conclusion. Our results show an increased adrenocortical production in nonobese PCOS women, not related to IR and associated with a normal hypothalamic-pituitary-adrenal suppression. Higher LH levels might be involved in this event.http://dx.doi.org/10.1155/2014/620605 |
| spellingShingle | Luciana Tock Gláucia Carneiro Andrea Z. Pereira Sérgio Tufik Maria Teresa Zanella Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome International Journal of Endocrinology |
| title | Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome |
| title_full | Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome |
| title_fullStr | Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome |
| title_full_unstemmed | Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome |
| title_short | Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome |
| title_sort | adrenocortical production is associated with higher levels of luteinizing hormone in nonobese women with polycystic ovary syndrome |
| url | http://dx.doi.org/10.1155/2014/620605 |
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