Head and neck tumor organoid biobank for modelling individual responses to radiation therapy according to the TP53/HPV status

Head and neck tumor organoid biobank for modelling individual responses to radiation therapy according to the TP53/HPV status

Abstract Background Head and neck cancers (HNC) represent an extremely heterogeneous group of diseases with a poorly predictable therapy outcome. Patient-derived tumor organoids (PDTO) offer enormous potential for individualized therapy testing and a better mechanistic understanding of the main HNC...

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Main Authors: Christian Issing, Constantin Menche, Mara Romero Richter, Mohammed H. Mosa, Jens von der Grün, Maximilian Fleischmann, Philipp Thoenissen, Ria Winkelmann, Tahmineh Darvishi, Andreas G. Loth, Shahram Ghanaati, Franz Rödel, Peter J. Wild, Christian H. Brandts, Timo Stöver, Henner F. Farin
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Head and neck squamous cell carcinoma
Tumor organoid biobank
Preclinical model
In vitro therapy testing
Radioresistance
Genetic editing
Online Access:https://doi.org/10.1186/s13046-025-03345-3
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https://doi.org/10.1186/s13046-025-03345-3

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