qBiCo: a method to assess global DNA conversion performance in epigenetics via single-copy genes and repetitive elements

qBiCo: a method to assess global DNA conversion performance in epigenetics via single-copy genes and repetitive elements

Abstract Background Human DNA methylation profiling offers great promises in various biomedical applications, including ageing, cancer and even forensics. So far, most DNA methylation techniques are based on a chemical process called sodium bisulfite conversion, which specifically converts non-methy...

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Bibliographic Details
Main Authors: Faidra Karkala, Roy B. Simons, Floor Claessens, Vivian Kalamara, Manfred Kayser, Athina Vidaki
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Epigenetics Communications
Subjects:
DNA methylation
Bisulfite conversion
Epigenetics
qPCR
Conversion efficiency
Quality control
Online Access:https://doi.org/10.1186/s43682-025-00033-3
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https://doi.org/10.1186/s43682-025-00033-3

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