Enhanced T-cell immunity and lower humoral responses following 5-dose SARS-CoV-2 vaccination in patients with inborn errors of immunity compared with healthy controls

Enhanced T-cell immunity and lower humoral responses following 5-dose SARS-CoV-2 vaccination in patients with inborn errors of immunity compared with healthy controls

ObjectivePatients with Inborn Errors of Immunity (IEI) are at higher risk of severe SARS-CoV-2 infection. We evaluated humoral and cellular responses to COVID-19 vaccines in Brazilian patients with IEI and healthy controls.MethodsFifty-five patients with IEI (13–61 years) and 60 controls (13–71 year...

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Bibliographic Details
Main Authors: Vitor Gabriel Lopes da Silva, Gabriela Justamante Händel Schmitz, Kathleen E. Sullivan, Júlia Barbate, Maria Izabel de Haro Azinar, Carolina Sanchez Aranda, Maria Isabel de Moraes-Pinto
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
COVID-19 vaccines
booster
inborn errors of immunity
primary immunodeficiency disorders
SARS-CoV-2
microarray
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538453/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538453/full

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