Targeting super-enhancers in liver cancer: from pathogenic mechanisms to clinical applications

Liver cancer, especially primary liver cancer (PLC), stands as the third leading cause of cancer-related mortality globally, posing a significant threat to human health. Super-enhancers (SEs), clusters of enhancer elements with high histone modifications and transcriptional activity levels, play cru...

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Bibliographic Details
Main Authors: Chang-Lei Li, Zhi-Yuan Yao, Ao Sun, Jing-Yu Cao, Zu-Sen Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1589455/full
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