Whole genome comparisons reveal gut-to-lung translocation of Escherichia coli and Burkholderia cenocepacia in two cases of ventilator-associated pneumonia in ICU patients

Whole genome comparisons reveal gut-to-lung translocation of Escherichia coli and Burkholderia cenocepacia in two cases of ventilator-associated pneumonia in ICU patients

Abstract Background Identifying the sources of pathogenic bacteria causing ventilator-associated pneumonia (VAP) in intensive care unit (ICU) patients is crucial for developing effective prevention and treatment strategies. However, the scarcity of reported cases with confirmed sources limits the ab...

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Main Authors: Huihui Gao, Lei Xu, Yixin Liu, Xiaolong Wang, Siyuan Zhu, Huai Lin, Yuting Gao, Daqing Mao, Xing Lu, Yi Luo
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Respiratory Research
Subjects:
Gut-to-lung pathogen translocation
Ventilator-associated pneumonia
Comparative genomics
Gut microbiome
Metagenomics
Online Access:https://doi.org/10.1186/s12931-025-03204-x
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https://doi.org/10.1186/s12931-025-03204-x

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