SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity

SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity

Abstract Transcribed CGG repeat expansions cause neurodegeneration in Fragile X‐associated tremor/ataxia syndrome (FXTAS). CGG repeat RNAs sequester RNA‐binding proteins (RBPs) into nuclear foci and undergo repeat‐associated non‐AUG (RAN) translation into toxic peptides. To identify proteins involve...

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Bibliographic Details
Main Authors: Indranil Malik, Yi‐Ju Tseng, Shannon E Wright, Kristina Zheng, Prithika Ramaiyer, Katelyn M Green, Peter K Todd
Format: Article
Language:English
Published: Springer Nature 2021-09-01
Series:EMBO Molecular Medicine
Subjects:
C9orf72 ALS
CGG repeats
FXTAS
RAN translation
SRSF
Online Access:https://doi.org/10.15252/emmm.202114163
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https://doi.org/10.15252/emmm.202114163

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