Metabolomics in drugs research on zebrafish-based cardiotoxicity models: endothelial and mitochondrial dysfunction, oxidative stress

Metabolomics in drugs research on zebrafish-based cardiotoxicity models: endothelial and mitochondrial dysfunction, oxidative stress

The aim. To investigate the metabolic profile of zebrafish embryos when exposed to drugs with known risks of cardiotoxicity, such as acetaminophen, carbamazepine, salbutamol, ketorolac, bisoprolol, and metoprolol. The analysis is aimed at detecting changes in the level of amino acids (including bran...

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Main Authors: N. E. Moskaleva, P. M. Rezvanov, V. M. Samoylov, V. G. Varzieva, S. N. Baskhanova, V. V. Tarasov, E. A. Smolyarchuk, D. A. Kudlay, S. A. Appolonova
Format: Article
Language:Russian
Published: Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute 2025-07-01
Series:Фармация и фармакология (Пятигорск)
Subjects:
cardiotoxicity
metabolomics
zebrafish
amino acids
acylcarnitines.
Online Access:https://www.pharmpharm.ru/jour/article/view/1681
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